Initial clinical evidence of this was provided by observational studies in high risk patients. Stratification of CV risk as well, in hypertensive patients in particular, has also been considered increasingly relevant: markers suggesting preclinical renal damage are also able to detect CV disease, and moreover be used to predict CV morbidity and mortality. The actual fact of composite interactions between CV disease, chronic kidney disease (CKD) and diabetes are becoming more widely accepted, however they are not completely understood, as yet ( 6). Furthermore, there is growing evidence revealing the continuous relationship between worsening in renal function and CV disease and a sharp increase in risk of CV morbidity and mortality ( 7) (Fig. Renal disease is a complication of diabetes and hypertension - which together make up the most common causes of chronic kidney disease (CKD) ( 6). 1 - Microalbuminuria is a CV risk factor in hypertensive patients However, CV disease may still progress under chronic RAAS blockade ( 5), and therefore microalbuminuria, as predictor of both CV and renal disease, should continue to be monitored in patients who are under chronic RAAS blockade therapy. They are preferred agents both in monotherapy or as components of combination therapy ( 4). Strong evidence from the 1980’s on, have put forward that suppressors of the renin-angiotensin-aldosterone system (RAAS) may have specific renal protective properties. Therefore, detecting microalbuminuria, just as scientific guidelines recommend, will screen for renal disease even in its early stages. When renal dysfunction starts to set in, proteinuria and microalbuminuria are predictors of development of renal and cardiovascular (CV) complications, -events and mortality ( 1, 2, 3). Co-existence of hypertension and diabetes increases the risk of renal and other target organ damage, and heads to greater incidence of cardiac events and mortality.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |